Clinical analysis of 286 cases of abdominal trauma with gastrointestinal tract laceration / 南方医科大学学报

<p><b>OBJECTIVE</b>To improve the diagnosis and treatment of abdominal injury.</p><p><b>METHODS</b>The clinical data of 286 patients with gastrointestinal tract laceration admitted between 2004 and 2009 to our hospital was analyzed.</p><p><b>RESULTS</b>The duration after trauma was 15 min to 2 days. Of the 286 patients eventually confirmed by laparotomy, 273 were cured, 3 showed improvement and 10 died.</p><p><b>CONCLUSION</b>Abdominal trauma in patients with gastrointestinal tract laceration, Abdominal puncture diagnosis and orthostatic abdominal X-ray are rapid and effective diagnostic methods for gastrointestinal tract laceration in patients with abdominal trauma. Laparotomy is the primary treatment measures and should be performed as early as possible.</p>

Changes in cyclooxygenase gene expression during spontaneous recovery from stress ulcer in rats / 南方医科大学学报

<p><b>OBJECTIVE</b>To observe the changes in gene expression of cyclooxygenase (COX) during spontaneous recovery from stress ulcer in rats exposed to water immersion and restraint stress (WRS).</p><p><b>METHODS</b>A rat model of stress ulcer was established by means of WRS, in which the changes in COX expression were detected with immunohistochemistry and reverse transcription (RT)-PCR.</p><p><b>RESULTS</b>Very low levels of COX-2 expression were detected in the gastric mucosa of the control rats, and the expression increased significantly during the healing process of the stress ulcer (P<0.05). COX-1 expression in the gastric mucosa showed no significant difference between the control group and the stress ulcer groups during healing (P>0.05).</p><p><b>CONCLUSION</b>COX-1 and COX-2 expressions in rat gastric mucosa during the recovery from stress ulcer participate in the recovery of the damaged mucosa possibly by mediating prostaglandin secretion.</p>